Given some of the thematic elements in Blomkamp's movies, it won't surprise me if Ripley somehow manifests in the film (or some cypher/substitute if Weaver is tired of dragging her character on) with a bit of an Alien DNA problem....but I kinda hope not since that was at least part of the many reasons Alien: Resurrection was such a bad movie.
It also won't be a "Prometheus 2" and will apprently take place an undefined amount of time after the sister franchise....which of course is reasonable. Anything else would only be worse and more confusing to the Alien/Prometheus Universe.
You know....I like everything he's done, and while I'm not too keen on a retcon film, I'll take what I can get when the odds are good the results will be worth it. Consider me intrigued at what Alien 5 will bring to the table now.